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Friday, December 29, 2023

 The recurrence rate is 30% within the first year

and 50% at 5 years. Patients with a family history of

kidney stones are more likely to develop stones, and

Caucasians are affected twice as often as African Americans and Asians. Specific risk factors for kidney stones

include dehydration, hypercalcemia, hyperuricemia

(gout), certain urinary tract infections (Proteus, Klebsiella,

Pseudomonas), and medications (protease inhibitors,

• Noncontrast computed tomography of the abdomen

and pelvis is the test of choice for diagnosing

nephrol ithiasis.

• Urologic consultation is indicated in patients with

coexisting infection or worsening renal insufficiency.

diuretics, laxatives). The 4 main types of kidney stones

are listed in Table 39-1.

The GU tract has several anatomic areas of narrowing

that may limit passage of a stone. The most common areas

are the renal calyx, the ureteropelvic junction (UPJ), the

pelvic brim (where the ureter passes over the pelvic bone

and iliac vessels), and the ureterovesical j unction (UVJ).

Ureteral obstruction occurs when a stone blocks the passage of urine, resulting in hydroureter (dilated ureter) and

hydronephrosis (dilated renal pelvis and calices).

Timely evaluation, a broad differential, and prompt

administration of appropriate analgesia is paramount to

proper emergency department (ED) management. Although

disposition of these patients is often uncomplicated, certain

factors may warrant more extensive workup, emergent urology consultation, and hospital admission.

Table 39-1 . Kidney stones by type, frequency of occurrence, and precipitants.

Stone Type

Calcium + phosphate/oxalate

Struvite (magnesium-ammoniumphosphate)

Uric acid

Cystine

Frequency

75%

1 0%

1 0%

<5%

Precipitants

Hyperparathyroidism, immobil ization

Infection caused by urea-spl itting bacteria Proteus (most common cause

of staghorn calculi)

Hyperuricemia

Hypercystinuria from genetic disorder

1 66

NEPHROLITHIASIS

CLINICAL PRESENTATION

.... History

Patients often present with rapid onset of severe sharp

pain, which is usually episodic ("renal colic") and lasts

minutes to hours. Pain often originates in the flank and

radiates to the abdomen and groin along the course of the

ureter. Nausea, vomiting, and diaphoresis are common.

Urinary symptoms, such as frequency and urgency, may

vary, depending on where the stone is located, and often

increase in severity when the stone nears the bladder .

.... Physical Examination

Patients with symptomatic nephrolithiasis are often rock ­

ing or writhing on the stretcher. They are frequently unable

to lie down or find a comfortable position. Elevated blood

pressure and heart rate are common because of pain.

Examination should focus on identifying and/or ruling out

other causes of abdominal and flank pain. It should

include a thorough genitourinary evaluation, including

pelvic or testicular examination, when pain is located in

the lower abdomen. Evidence of a pulsatile abdominal

mass or peritonitis suggests an alternative diagnosis.

DIAGNOSTIC STUDIES

.... Laboratory

Although no single laboratory test is needed to diagnose

kidney stones, there are several that are critical for management and disposition. Urinalysis is performed to assess for

hematuria and the presence of concomitant infection. In

15-30% of patients, microscopic hematuria may be absent.

Crystals may be present in the urine and aid in the

diagnosis of stone type. Urine pH >7.6 (normal is 5.5) may

indicate infection with urea-splitting organisms. Urine

pregnancy test should be obtained in all females of

childbearing age to rule out the possibility of ectopic pregnancy. Blood urea nitrogen and creatinine are often

checked to assess renal function, especially in patients at

risk for renal insufficiency (diabetics, elderly) or in patients

who may receive intravenous (N) contrast. Complete

blood count may be helpful when infection is suspected,

but is not routinely necessary .

.... Imaging

Computed tomography (CT) scan of the abdomen and

pelvis is the test of choice for diagnosis of nephrolithiasis

(Figure 39-1). It has a sensitivity and specificity of approx ­

imately 96% for kidney stones. CT scans can visualize all 4

types of kidney stones as well as perinephric stranding,

hydroureter, and hydronephrosis. They can also identify

nonurologic causes of pain (eg, abdominal aortic aneurysm [AAA]) in cases of diagnostic uncertainty.

Noncontrast CT scan does not evaluate renal function or

the presence of complete obstruction.

.&. Figure 39-1 . CT sca n of left ureteral stone (arrow).

Renal ultrasound may also be considered as an imaging

option,

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