med 18

 

 Appendix C 413

Table C.1 Blood Products (Continued)

Platelet Products

Products Volume (mL) Shelf Life Advantages Disadvantages Comments

A. Platelet concentrate

(random donor

platelets)

45–60 5 d Approximately 5.5 ×

1010 platelets in

45–60 mL plasma

1. Contains some

WBCs, few RBCs,

and plasma

2. Rh D immunization

possible

1. Use immediately on

receipt from blood

bank and never

refrigerate

2. May be leukocytereduced but need

2–3 u. pool for efficient LD

3. Volume may be

reduced by centrifugation for use when

out of group or

extreme volume

restriction is necessary; changes expiration to 4 h

B. Single-donor apheresis platelets

250–300 5 d 1. >3 × 1011 platelets in

250–300 mL of

plasma

2. Always LD with current collection

equipment

3. If used over 5 d, can

reduce donor exposures.

4. Repeated pheresis

from some donor

possible

1. Large volume; needs

to be split or aliquoted into EUs.

1. Allows selection of

HLA- and HPAcompatible donors

2. 1 EU = 5.5 × 1010

platelets

3. Std dose = 1 EU/5–

10 kg with minimum dose of one

EU (volume reduction may be necessary for ELBW

infants)

Plasma Products

Products Volume (mL) Shelf Life Advantages Disadvantages Comments

A. FFP 180–300 Frozen

(–18 °C) = 1 yr

Thawed = 24 h

1. Contains plasma

proteins, coagulation factors, anticoagulant proteins,

complement, and

albumin

1. 20–45 min thawing

time

2. Not for volume

expansion or fibrinogen replacement

1. Separated from WB

within 6–8 h collection

2. Must be ABOcompatible

3. Use blood filter

4. Confused with F24,

now more commonly available

B. Cryoprecipitate 10–25 Frozen

(–18 °C) = 1 yr

Thawed = 4 h

1. Better source of

fibrinogen and

VWF than plasma

products

1. Limited indications

include F XIII and

congenital/acquired

fibrinogen deficiency

1. Must be ABOcompatible

2. Use blood filter

3. Transfuse immediately after thaw

4. Dose = 1 U/5–10 kg

but small volume

confusing

C. Albumin 5% 3 yr at room temperature

1. Heat-treated to

reduce risk of infectious diseases

2. Requires no crossmatch

3. Increases plasma

oncotic pressure

1. Expense

2. Does not provide

coagulation factors

1. Five micron filter

required

2. Na 145 mEq/L

3. Osmolarity 300

MOs m/L